Evolution of blood–brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies
نویسندگان
چکیده
منابع مشابه
Nanoscale drug delivery systems and the blood–brain barrier
The protective properties of the blood-brain barrier (BBB) are conferred by the intricate architecture of its endothelium coupled with multiple specific transport systems expressed on the surface of endothelial cells (ECs) in the brain's vasculature. When the stringent control of the BBB is disrupted, such as following EC damage, substances that are safe for peripheral tissues but toxic to neur...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica Sinica B
سال: 2020
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2020.11.023